Moreover, CD31 (endothelial cell marker) in those CWR22Rv1 xenograft tissues was stained by immunohistochemistry (IHC) assay, and fewer CD31-positive tumor tissues in CWR22Rv1/LV3-miR-218 group was observed than that from the control group (Figure 5C). This evidence concerns the gene PECAM1 and neoplasm.