Furthermore, on investigating the set of genes differentially expressed upon AML1-ETO knockdown in t(8;21) cells [5] in inv(16) AML cells before and after knockdown of CBFB-MYH11 revealed differential expression of 45% of genes (Supplementary Figure 1A and Supplementary Table 1). This evidence concerns the gene RUNX1 and acute myeloid leukemia.