RUNX1 and acute myeloid leukemia: To identify the common binding and gene program of oncofusion proteins associated with AML we used previously identified target regions of PML-RARA in the t(15;17) NB4 cell line [10], AML1-ETO in the t(8;21) Kasumi-1 cell line [6] and CBFB-MYH11 in the inv(16) ME-1 cell line [9] for further analysis (Figure 1A).