However, upon stimulation with FAM150A (AUG-β) or FAM150B (AUG-α) ligands both ALK-L1198F and ALK-G1201E were able to mediate neurite outgrowth, although at levels less than those observed with wild type ALK or the constitutively active ALK-F1174L neuroblastoma mutant (Figure 2A and 2C). Here, ALK is linked to neuroblastoma.