Interestingly, the top two upregulated genes in melanomas from RHC were PRKAA1 (fold change=1.37, p=0.08) and PIK3C3 (fold change=1.23, p=0.09) while the top two downregulated were YWHAG (fold change=0.62, p=0.29) and CLN3 (fold change=0.77, p=0.3). This evidence concerns the gene CLN3 and melanoma.