KLF5 and breast cancer: In order to test whether the induction of KLF5 expression by Dex also contributes to Dex-induced mediated drug resistance in other types of breast cancer cells other than TNBC, we treated ER-positive breast cancer cell MCF7 with Dex and found KLF5 expression indeed is induced by Dex in a time course-dependent manner (supplementary Figure 2C).