COMT and DGCR8 were de novo deleted in two SA females in the schizophrenia-associated 22q11.2 CNV (Table 2), but COMT is also one of the earliest SB candidate genes [51] with shown SNP-association and brain expression alterations, and DGCR8 also showed SNP-association [8]. The gene discussed is COMT; the disease is schizophrenia.