They also showed that, in isolated hepatic stellate cells, hypoxia activated both HIF-1α and HIF-2α, leading to increases in profibrotic gene expression [38], and that deletion of HIF-1α in Mx interferon-expressing cells resulted in reduced liver fibrosis in a bile duct ligation model of cholestatic liver injury, via dysregulation of similar profibrotic mediators [39]. This evidence concerns the gene EPAS1 and Hepatic fibrosis.