Regarding longitudinal trend analysis with a linear regression model we were able to detect a linear increment of ab-level after study inclusion in POAG + ODH patients with r-values ≥ 0.8 (anti-AP1M1 ab, anti-SPRY ab: r = 0.84; R2 = 0.7). The gene discussed is AP1M1; the disease is open-angle glaucoma.