With respect to the immunoreactivities at time point 1 we were able to identify changing level of anti-adaptor protein 1 (AP-1) complex subunit mu-1 (AP1M1)-level (Q9BXS5 [28], Fig 4) and anti-SPRY domain-containing SOCS box protein 3 (Q6PJ21 [28], SPSB3)-level (Fig 5) over the study period in the POAG + ODH group with respect to the POAG group. Here, SPSB3 is linked to open-angle glaucoma.