FASN and fatty liver disease: Several studies on mice with hepatic steatosis have shown that several transcription factors and components of the triacylglycerol metabolism such as PPARγ (Pparg), fatty acid synthetase (Fasn), SREBP-1c (Srebf1) and stearoyl-coenzyme A desaturase 1 (Scd1) are increasingly expressed in the liver.