Results show that the tumor growth in RNF2 knockdown group (shRNF2 #1 and shRNF2 #2) was dramatically inhibited compared with the control (shScr) group, with the final tumor volume of 304.33±63.72 mm3, 331.93±84.42 mm3 and 846.80±55.29 mm3, respectively (p<0.05, Figure 3C). Here, RNF2 is linked to neoplasm.