RNF2 and posterior cortical atrophy: The RNF2 expression level was also analyzed with PCa tumor grade, and results showed that the RNF2 expression was significantly higher in high grade PCa(Gleason>7) (H-Score: 150.5±62.03) than low grade PCa(Gleason≤7) (H-Score: 97.10±53.63) (Figure 1C).