A recently identified tumor suppressor in NPC [56] and esophageal carcinoma, cysteine-rich intestinal protein 2 (CRIP2) encoded by a gene on chromosome 14 has been shown to inhibit NF-κB-dependent proangiogenic cytokine transcription in NPC cells, and its ectopic expression triggers apoptosis in esophageal carcinoma [57]. The gene discussed is CRIP2; the disease is carcinoma of esophagus.