Studies focused in HCC (hepatocellular carcinoma) found that most of the Mφ was unique phenotype with expression of low HLA-DR (human leukocyte antigen-antigen D related) and high IL-10 in the tumor nests but another different phenotype with expression of moderate HLA-DR and negative IL-10 in the peritumoral stromal region [26]. Here, IL10 is linked to hepatocellular carcinoma.