In univariate model, nodal status of N3 and N2 [HR: 3.28 (1.54–6.95); p=0.002], TNM stages of IV [HR: 4.64 (2.34–9.20); p=0.000], stromal TILs≥10% [HR: 0.52 (0.27–0.99); p=0.045], high count of stromal FXOP3+ Tregs [HR: 1.95 (1.01–3.75); p=0.045], high count of stromal CD68+ Mφ [HR: 2.24 (1.16–4.34); p=0.017] and high expression of FOXP3 in cancer cells [HR: 0.49 (0.25–0.99); p=0.048] had an independent effect on the risk of death (Table 3). The gene discussed is FOXP3; the disease is cancer.