CRYBB2 and neoplasm: Specifically in the present study's supervised whole genome expression analysis between 58 black and 58 white propensity score matched patients with pRCC, we identified a distinct tumor biology as demonstrated by enrichment of immune related pathways including the B cell receptor signaling pathway, NOD-like receptor signaling pathway, and genes involved in defensins, VEGF and more specifically overexpression of CRYBB2 associated with the WNT signaling pathway in black patients.