This region harbors a large number of androgens modulated and prostate cancer (PC) related genes, including the proteases prostate specific antigen, kallikrein 1 (KLK1), kallikrein related peptidase 2 (KLK2) [2], the apoptotic regulator BCL2 associated X (BAX) [3], kallikrein related peptidase 11 (TLSP) [4] or kallikrein related peptidase 6 (Zyme/Neurosin) [5]. This evidence concerns the gene KLK2 and pachyonychia congenita.