Further implicating alpha-synuclein misfolding in the pathogenesis of neurodegenerative diseases, duplications and triplications of the alpha-synuclein gene (Singleton et al. 2003; Ibáñez et al. 2004), as well as six different point missense mutations have been found to cause either PD or DLB. This evidence concerns the gene SNCA and Lewy body dementia.