Further implicating alpha-synuclein misfolding in the pathogenesis of neurodegenerative diseases, duplications and triplications of the alpha-synuclein gene (Singleton et al. 2003; Ibáñez et al. 2004), as well as six different point missense mutations have been found to cause either PD or DLB. Here, SNCA is linked to neurodegenerative disease.