It has been reported that Rb-mediated gene expression repression of E2F2 (transcription factor 2), by acting to tether Rb to specific E2F promoter sites, was crucial in T cells, and mutation of E2F2 in mice resulted in enhanced T lymphocyte proliferation leading to the development of autoimmunity (Murga et al., 2001). The gene discussed is E2F2; the disease is Autoimmunity.