APP and Alzheimer disease: Neuronal Akt signaling is inhibited by oligomeric Aβ23 and Akt activity is diminished in brains of AD patients and of APP trangenic mice.40 NGF deprivation also rapidly decreases Akt phosphorylation/activity.27 FoxO transcription factors are well-described Akt targets that are activated when Akt signaling is suppressed,41 and FoxO activation occurs and is required for neuronal death induced by trophic factor deprivation and Aβ exposure.18,23,26,27 These considerations suggested that Cdc25A might be regulated by FoxOs.