It has been reported that neurons in post-mortem brains from AD patients have elevated Cdc25A immunostaining and that brain tissue from AD patients has higher Cdc25A phosphatase activity compared with non-AD brains.37 Chang et al.38 found that Aβ activates Cdc25A, B and C in cultured neurons and that a broad-spectrum Cdc25 inhibitor protects from Aβ-induced death. The gene discussed is CDC25A; the disease is Alzheimer disease.