We utilized cultured neuroblastoma cells with normal endogenous N-Myc expression (SH) as the control in which N-Myc was ectopically overexpressed constitutively (SH-N-Myc) to determine the impact of N-Myc because they were isogenic and c-Myc was undetectable (Supplementary Figure 7), which eliminated this as a confounding factor. Here, MYCN is linked to neuroblastoma.