TNFRSF10B and melanoma: This is valuable new information on the efficacy of hvTRA in melanoma and, to our knowledge, the first study where a TRA has been combined with a MAPK/ERK inhibitor in vivo. Additional studies are warranted to conclude if it is possible to take advantage of the cytotoxic effect of combining hvTRA and vemurafenib before vemurafenib-mediated downregulation of DR5.