EDNRB and hypertensive disorder: Furthermore, ETB receptors in peripheral ganglia can influence BP,36 suggesting that sympathetic activation accounts for ETB-induced hypertension.37 In contrast, BP was not elevated by ECETB KO.22 The small (≈4 mm Hg) increase in BP, which persisted in SMETB KO mice despite reduced heart rate, suggests that loss of SMETB contributes to the increased BP induced by systemic ETB antagonism20 or global ETB deletion.10 However, it requires rejection of our hypothesis that ETB-mediated vascular contraction contributes to BP elevation.