These affect a total of five genes: PTEN (I32del [AF: 2.1%], R130G [AF: 2.4%], G165E [AF: 2.3%]), PIK3R1 (Y463_L466del [AF: 5.5%], E558fs [AF: 1.6%]), PIK3CA (Q546K [AF: 5.1%], C420R [AF: 1.5%]), KRAS (G12S [AF: 1.2%], G12C [AF: 6.3%], G12C [AF: 1.4%]), and FGFR2 (S252W [AF: 5.8%]). The gene discussed is FGFR2; the disease is atrial fibrillation.