DNMT3A and leukemia: Results from three nearly back-to-back whole-exome [58,59] and gene panel targeted sequencing studies [60] on nearly 34,000 individuals identified clonal hematopoiesis with leukemia-related, somatic driver mutations, most notably DNMT3A, in 10% of apparently healthy individuals >65 years of age and in nearly 20% in those between 90 to 108 years of age [58,59].