Knockdown studies of these (de)methylases further revealed their involvement in many significant physiological processes including obesity [24–26], synaptic signaling [27], cancer [28, 29], sperm development [22], stem cell differentiation [30], circadian periods [31], yeast meiosis [32, 33], and stem cell pluripotency [34–36]. Here, MBD2 is linked to obesity due to melanocortin 4 receptor deficiency.