The significant overlapping pathways between METTL3 and METTL14 include Glioma (20 mDrGenes in KD-METTL3, pBonferroni = 1.37×10−6, 13 mDrGenes in KD-METTL14, pBonferroni = 1.85×10−3), suggesting that these mDrGenes may be used as biomarkers of glioma. The gene discussed is METTL3; the disease is central nervous system cancer.