COL2A1 and neoplasm: An additional four genes involved in construction of tumor morphology were also reported to act as tumor suppressors, including RELN (serine protease degrading ECM)[25], HS3ST1 (ECM remodeling gene)[26], PCDH17 (cell adhesion gene)[27], and ANGPTL4 (matrix-associated gene)[28]; these four genes shared similar expression patterns as Wnt5A. In contrast, 3 of the 24 genes (ARG2, COL2A1, FMOD) showed significantly higher expression in tumor samples than in normal samples in both the DASL and TCGA data.