APH1A and early-onset autosomal dominant Alzheimer disease: According to the KEEG database, APH1A, BACE-1, CAPN1, CAPN2, CDK5, CDK5R1, DYRK1A, IDE, PSEN1, PSEN2, PSENEN, MAPT, and NCSTN belong to the Alzheimer’s Disease pathway in a statistical manner, FDR = 4.19 × 1015.