In cancer cells, genetic mutations and abnormal gene expression are widespread in the extrinsic and intrinsic apoptotic pathways, as previous studies have shown with increased expressions of anti-apoptotic proteins FLIP, Bcl-2, Bcl-XL, or MCL-1 and with mutations in p53, APAF-1, Bax, Fas, FADD, or caspases [59,121]. This evidence concerns the gene BCL2 and cancer.