When the mTOR-mediated phosphorylation of 4EBP1 was blocked in MYC driven cancers by MLN0128, which specifically blocks the mTOR active site by inhibiting 4EBP1 phosphorylation, it specifically induced significant apoptosis in the MYC driven pre-tumor B cells, while sparing the wild type B cells. Here, EIF4EBP1 is linked to cancer.