The Th2 cytokines such as interleukin 4 (IL-4), IL-5, and IL-13 are reported to be predominant in the acute phase of AD, and in chronic AD lesions, an increase in IFN-γ, IL-12, IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been noted [34]. This evidence concerns the gene CSF2 and Alzheimer disease.