SIRT1 and Hepatic fibrosis: A highly conserved lncRNA, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), has been demonstrated to have a strong propensity to interact with SIRT1. MALAT1 increases in liver fibrosis and mediates the degradation or inactivation of SIRT1 through its association with the histone deacetylase SIRT1 [111].