The increased mRNA and protein levels of Cfl-1 in comparison with control (nonmalignant) cells have been shown in various HMCs including those from breast [140], lung [142], prostate [149] etc. Overexpression of Cfl-1 has been mainly associated with tumor cell proliferation, invasion, and metastasis [14,140,150,151]. This evidence concerns the gene CFL1 and neoplasm.