The tumor suppressor protein phosphoinositide phosphatase and tensin homolog (PTEN) may inactivate cofilin in cancer cells, while loss of PTEN and activation of phosphoinositide 3-kinase (PI3K) caused differential activation of the cofilin regulators, LIMK1 and SSH1L, and cofilin dephosphorylation, that promote microtentacles formation and enhance metastatic risk [170]. This evidence concerns the gene CFL1 and cancer.