The controversial data on the role of dephosphorylated Cfl-1, LIMK1, mAbp1, and GMF-B in cell motility, invasion and metastasis may have several possible reasons including different cell types used in the studies, intratumoral cell heterogeneity, distinct functions of studied proteins at different stages of development or tumor progression, cellular background, etc. All these factors should be taken into account, and the collective activity of cofilin-regulating pathways should be estimated for evaluation of the invasive and metastatic potential of HMCs. Here, GMFB is linked to neoplasm.