SCN5A and familial long QT syndrome: For example, an eight‐generation family carrying SCN5A+/1795insD showed bradycardia and TdP episodes, characteristic of LQTS3, and ECG ST segment elevation and high rates of nocturnal SCD, characteristic of BrS.36 In addition to the effects of ageing, gender can affect LQTS phenotypes: women show longer QTc intervals than men, increasing predisposition to polymorphic ventricular tachycardia.37, 38 In LQTS1 and LQTS2, women are at higher risk of TdP than men.