A theoretical concern for an anti-MAG antibody is the potential to cause a demyelinating peripheral neuropathy, however, the Fc region of GSK249320 is disabled, preventing the complement fixation that is central to the pathophysiology of anti-MAG antibody neuropathy [13], and furthermore the anti-MAG antibodies associated with neuropathy are IgM not IgG [14]. This evidence concerns the gene MAG and neuropathy.