CD47 and anemia: Indeed, the involvement of CD47 in anemia was also observed in mild autoimmune hemolytic anemia typical of experimental nonobese diabetes, which was worsened and became lethal in CD47-deficient mice (Oldenborg et al., 2002) and in patients with myelodysplastic syndrome, the degree of anemia was correlated to the levels of CD47 expressed on erythroblasts (Jiang et al., 2013).