CD47 and parasitic infectious disease: Similar results in a more recent study (Ayi et al., 2016) showed that CD47-deficiency attenuated parasitemia and abolished the development of cerebral malaria in P. berghei ANKA-infected mice, as well as P. falciparum-pRBC had decreased levels of CD47, a phenomenon that was associated with both in vitro and in vivo clearance of P. falciparum—and P. berghei-pRBCs via SIRPα, respectively.