Indeed, the involvement of CD47 in anemia was also observed in mild autoimmune hemolytic anemia typical of experimental nonobese diabetes, which was worsened and became lethal in CD47-deficient mice (Oldenborg et al., 2002) and in patients with myelodysplastic syndrome, the degree of anemia was correlated to the levels of CD47 expressed on erythroblasts (Jiang et al., 2013). The gene discussed is CD47; the disease is myelodysplastic syndrome.