To determine if effector T-cells played a role in mediating this enhanced protection, and, if so, which subsets might be involved, groups of mice were vaccinated three times over 3 weeks to develop vaccine-specific effector responses and then were challenged with tumor under differing depletion conditions: depleting CD4+, CD8+, both CD4+ and CD8+, and no depletion of T cells. Here, CD4 is linked to neoplasm.