For DNA vaccines, addition of MIP3α to circumsporozoite protein (CSP) with vaxfectin adjuvant [30] creates a robust, protective antibody response against malaria, addition of MIP3α to oncofetal antigen (OFA) given by gene gun creates a therapeutic response against lymphoma mediated by CD8+ T-cells [31], and as reported here, addition of MIP3α to gp100 given by intramuscular electroporation creates a therapeutic response against melanoma mediated by both CD4+ and CD8+ effector T-cells. The gene discussed is PMEL; the disease is melanoma.