Antigens expressed on leukemia blasts or preferentially expressed on leukemia stem cells including CD33, CD45, CD96, CD123, CD135, CLL-1 and T cell immunoglobulin mucin-3 (TIM-3) represent potential targets for antibody-based therapy in AML [160, 161]. The gene discussed is HAVCR2; the disease is acute myeloid leukemia.