Consistent with these observations, the diversity of the responding cells (CD107a+IFNγ+) was lower in 8 of 10 donors cocultured with autologous LCL compared to primary B cells (Figure S5 in Supplementary Material); this reduced diversity also suggests that the specific response to EBV infection may be driven by a subset of EBV-responsive NK cells. This evidence concerns the gene IFNG and Epstein-Barr virus infection.