Treatment of mice with a point mutation in the GR DNA-binding domain that impairs formation of transactivating GR dimers (GRdim) and mice lacking GR in macrophages with recombinant IL-1 receptor antagonist improves their survival after LPS challenge confirming that regulation of IL-1β in macrophages by GCs plays essential role in the control of sepsis (196). Here, NR3C1 is linked to Sepsis.