The same Fc motif was applied to the MGA271 mAb (anti-CD276), which targets B7-H3+ tumor cells and resulted in an increased binding to FcγRIIIa, enhanced ADCC, and potent antitumor activity in a renal cell carcinoma/bladder cancer xenograft mouse model (58). The gene discussed is CD276; the disease is urinary bladder carcinoma.