The serum levels of HMGB1 were significantly higher in patients with HT (37.81 ± 12.26 ng/mL) and in patients with GD (40.03 ± 13.40 ng/mL) than in control subjects (17.54 ± 4.94 ng/mL, P < 0.01, and P < 0.01, respectively, Figure 8A). Here, HMGB1 is linked to hematocrit.