Interestingly, it has recently been shown that synergic induction of COX-2 by IFN-γ and TNF-α limits type-1 immune response in tumor microenvironment by concomitant action of IL-10, NOS2, and Indoleamine 2,3-dioxygenase (Wong et al., 2016). The gene discussed is NOS2; the disease is neoplasm.