NR1H3 and metabolic syndrome: Conversely, overexpression of nr1h3 in enterocytes confers protection from dyslipidemia and hepatic steatosis when animals are fed a HFD; this metabolically beneficial effect of nr1h3 overexpression is due to the induction of a transcriptional program resulting in temporary enterocyte storage of lipids, delaying an en masse delivery of atherogenic lipoprotein particles in the circulation.