CASR and neonatal severe primary hyperparathyroidism: Thus, in a transgenic mouse in which parathyroid-specific ablation of Gαq was produced on a global Gα11 null background, severe neonatal hyperparathyroidism was observed (Wettschureck et al., 2007) and resembled the phenotypes of both global (Ho et al., 1995) and parathyroid-specific (Chang et al., 2008) ablation of the CaSR.