The impact of gene dosage on the severity of autosomal dominant hypocalcemia has been evaluated in a mouse model, the Nuf mouse (L723Q, affecting a residue at the C-terminal end of iL-2), which exhibits hypocalcemia, suppressed serum PTH levels, hypocalciuria, hyperphosphatemia, and ectopic mineralization and cataracts (Hough et al., 2004). This evidence concerns the gene PTH and autosomal dominant hypocalcemia.