Interestingly, emerging literature data reported that MDM2 inhibition played a role not only in apoptosis induction but also in autophagy activation in different hematological malignancies, like multiple myeloma (Gu et al., 2014) and acute myeloid leukemia (AML; Borthakur et al., 2015). This evidence concerns the gene MDM2 and acute myeloid leukemia.