Finally, p53 was also inactivated by the frequent deletion of CDNK2A (Usvasalo et al., 2008; Iacobucci et al., 2011) and the overexpression of MDM2 in ALL patients (Zhou et al., 1995, 2000; Gu et al., 2008). The gene discussed is TP53; the disease is acute lymphoblastic leukemia.