More specifically, Ang-(1-7) attenuated the induction of iNOS, a NO-generating enzyme that is found over-activated in a series of vascular diseases running with low grade inflammation, such as atherosclerosis, hypertension or diabetic vasculopathy (Shimokawa and Tsutsui, 2010; Di Pietro et al., 2013; Oliveira-Paula et al., 2014). This evidence concerns the gene NOS2 and hypertensive disorder.