The transcription factor NF-κB is a main redox-sensitive regulator of iNOS expression (Teng et al., 2002; Zahradka et al., 2002), and its over-activation by a wide array of stimuli has been associated to chronic inflammatory vascular diseases, such as atherosclerosis (Monaco et al., 2004). The gene discussed is NFKB1; the disease is atherosclerosis.