SCARB1 and Familial prostate cancer: Danilo et al. (2013) found that mice bearing a MDA-MB-231 xenografts had significantly increased microvessel density in the control tumor when compared to the SR-B1 knockdown tumor. In the TRAMP mouse model of prostate cancer, mice fed a high-fat, high-cholesterol Western-style diet had decreased plasma HDL cholesterol levels, increased tumor expression of SR-B1 and increased tumor angiogenesis (Llaverias et al., 2010).