SR-B1 has been found to be highly expressed in several different types of tumors including breast, ovarian, colorectal, pancreatic cancer (Shahzad et al., 2011) and prostate cancer (Schörghofer et al., 2015) with relatively low expression in most healthy tissue (Rhainds and Brissette, 2004). Here, SCARB1 is linked to Familial prostate cancer.