MAPT and Alzheimer disease: Cumulative evidence demonstrates that Aβ and tau are neurotoxic and can trigger a cascade of neurodegenerative processes ending in neuronal death, suggesting that overproduction/accumulation of Aβ and tau in vulnerable brain regions is the primary influence driving AD pathogenesis (Hardy and Selkoe, 2002; Gautam et al., 2015; Golovyashkina et al., 2015; Popugaeva et al., 2015).