In addition, decreased soluble UCHL1 protein levels was detected in the brains of postmortem AD patients and APP/PS1 mouse models (Choi et al., 2004; Gong et al., 2006), and soluble UCHL1 is inversely proportional to the number of NFTs in AD brains (Choi et al., 2004). The gene discussed is UCHL1; the disease is Alzheimer disease.