In addition, decreased soluble UCHL1 protein levels was detected in the brains of postmortem AD patients and APP/PS1 mouse models (Choi et al., 2004; Gong et al., 2006), and soluble UCHL1 is inversely proportional to the number of NFTs in AD brains (Choi et al., 2004). This evidence concerns the gene APP and Alzheimer disease.