PRKN and Parkinson disease: Major pathological features of PD include intraneuronal accumulation of Lewy bodies and dystrophic neurites (Lewy neurites), both of which comprise aggregated proteins, such as α-synuclein, parkin, and ubiquitinated proteins (Hughes et al., 1992; Braak et al., 2003; Chiasserini et al., 2015; Xiang et al., 2015).