For example, simvastatin (Xu et al., 2013; Gao et al., 2016; Zhou et al., 2016) and memantine (Xu et al., 2012; Wei et al., 2016) used in Parkinson's diseases, attenuate the 6-OHDA-induced inflammation and Nur77 cytosolic translocation. Here, NR4A1 is linked to Parkinson disease.