This crucial role of WT ataxin-2 in maintaining mRNA stability and regulating translation might also explain the reason for ataxin-2 being associated with several other neurodegenerative diseases like ALS, SCA1, and MJD (Uchihara et al., 2001; Al-Ramahi et al., 2007; Lessing and Bonini, 2008; Elden et al., 2010; Nóbrega et al., 2015). This evidence concerns the gene ATXN2 and neurodegenerative disease.