As activator of other protooncogenes such as Rapidly Accelerated Fibrosarcoma (RAF) kinases [21], Phosphoinositide-3-Kinase (P13K) [22], Afadin (AF6) [23], and Guanine Nucleotide Exchange Factors (GEFs) [24], MRAS also triggers Mitogen-Activated Protein Kinases/Extracellular Signal-Regulated Kinases- (MAPK/ERK-) independent gene expression in breast cancer cells [25]. This evidence concerns the gene AFDN and breast cancer.