Indeed, the association of ACTB with a wide range of cancer types (liver, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, and ovarian cancers and leukemia, melanoma, and lymphoma) has been explained [34] and that of ACTBL2 in some hepatocellular carcinoma has been reported [35]. The gene discussed is ACTBL2; the disease is melanoma.