VPS33B is ubiquitously expressed, including expression in the vestibulocochlear ganglion (Diez-Roux et al., 2011), and disruption of VPS33B-dependent intracellular protein trafficking and collagen homeostasis may also underlie the sensorineural deafness of patients with ARKID and ARC. This evidence concerns the gene VPS33B and sensorineural hearing loss disorder.