The SCLtTA/BCR-ABL model has also been used to explore the role of the microenvironment in CML development, with studies indicating that leukemic myeloid cells can remodel the endosteal BM niche into an environment that impairs normal hematopoiesis and promotes leukemic progression [61], and that specific cytokines produced by leukemic cells can influence the BM microenvironment to provide favorable conditions for CML LSC growth [62]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.