Two published meta-analyses, one of 12 and another of 13 studies, reported significant association with ALS for pooled analyses of ATXN2 alleles greater than 30 trinucleotide repeats, a finding that remained significant when restricted to alleles sized between 30 and 33 repeats (Laffita-Mesa et al., 2012, Wang et al., 2014). This evidence concerns the gene ATXN2 and amyotrophic lateral sclerosis.